In Vitro and In Vivo Evaluation of Microspheres Loaded Topical Gel Delivery System of Ketoconazole in Male Rats against Candida Glabrata

Ketoconazole topical is an antifungal medication. Ketoconazole topical prevents fungus from growing on your skin. The aim of the present investigation was to design and formulate an appropriate microspheres loaded gel (MLG), and explore the parameters affecting the morphology and other characteristics of the resultant products employing scanning electron microscopy (SEM). Microspheres loaded topical gel has been shown that encapsulation and controlled release of ketoconazole could reduce the side effect while also reducing percutaneous absorption when administered to the skin. The particle size ranged from 30-120 μm and the microspheres loaded gel was found to be in the range 6999 to 18596 cps. The MLG formulations exhibited maximum gel strength was found to be (35 sec.), highest value of mucoadhesion force was found to be (26.72 dynes/cm), and remarkable spreadability was found to be (4.44 gm.cm/sec). The microspheres were incorporated in various concentrations of gel formulations and the drug release from these formulations was up to 12 hours.